Background: Atorvastatin, an inhibitor of 3-hydroxy-3-methylglutarylcoenzyme-A (HMG-CoA) reductase, is widely prescribed in adult and pediatric patients for its potent cholesterol lowering effect. However, atorvastatin is only commercially available in tablet form. Therefore, pharmacists have compounded atorvastatin suspension making the medication available to more pediatric patients and select adults unable to take tablets. Limited reports on the preparation of atorvastatin suspension and lack of chemical stability data has relegated pharmacists to prepare a maximum 2-week supply of suspension per United States Pharmacopeia (USP) guidelines...........

Keywords : Stability; Chemical stability; HPLC; Suspension; Physicochemical properties; US Pharmacopeia (USP).

[1]. Lexicomp Online L-DO: Wolters Kluwer Health, Inc. Atorvastatin 2021. Available at: http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/6396?cesid=5X8q1ar9aaE&searchUrl=%2Flco%2Faction%2Fsearch%3Fq%3Datrovastatin%26t%3Dname%26va%3Datrovastatin. Accessed February 15, 2021.
[2]. Rollins DE, Blumenthal DK. Drug Therapy of Dyslipidemias. Workbook and Casebook for Goodman and Gilman's The Pharmacological Basis of Therapeutics. New York, NY: McGraw-Hill Education; 2016:948-53.
[3]. Zaid AN, Assali M, Zalmout S, Basheer A. Compounding and stability evaluation of atorvastatin extemporaneous oral suspension using tablets or pure powder. Eur J Hosp Pharm. 2017;24(3):157-61.
[4]. Goel A, Baboota S, Sahni JK, Srinivas KS, Gupta RS, Gupta A, et al. Development and validation of stability-indicating assay method by UPLC for a fixed dose combination of atorvastatin and ezetimibe. J Chromatogr Sci. 2013;51(3):222-8.
[5]. Oliveira MA, Yoshida MI, Belinelo VJ, Valotto RS. Degradation kinetics of atorvastatin under stress conditions and chemical analysis by HPLC. Molecules. 2013;18(2):1447-56.

Microorganisms are highly susceptible to skin lesions, especially bacteria. The examples of bacteria that infect the skin are S.aureus, S.epidermidis, and Methicillin Resistant Staphylococcus aureus. Nowdays, many bacteria have resistance to the antibiotics, so an alternative could be effective in inhibit the growth. Calendula are plants with antioxidant, antifungal, and anti-inflammatory activity. Tea tree oil has antifungal, antiviral, antiprotozoal, and antibacterial activity. The aim of the study is to identify the antibacterial activity of the essential oil of calendula, tea tree, and the combination of calendula and tea tree to againstS.aureus, S.epidermidis, and MRSA...........

Keywords : Calendula, MRSA, Staphylococcus aureus, Staphylococcus epidermidis, Tea Tree.

[1] E. A. Grice and J. A. Segre, "The Skin Microbiome," Nat. Rev. Microbiol., vol. 9, no. 4, pp. 244–253, 2011, doi: 10.1038/nrmicro2537.The.
[2] C. Schmidt, "Out of Your Skin," Nat. Biotechnol., vol. 38, no. 4, pp. 392–397, 2022, doi: https://doi.org/10.1038/s41587-020-0473-8.
[3] C. F. Carson, K. A. Hammer, and T. V. Riley, "Melaleuca alternifolia (tea tree) oil: A review of antimicrobial and other medicinal properties," Clin. Microbiol. Rev., vol. 19, no. 1, pp. 50–62, 2006, doi: 10.1128/CMR.19.1.50-62.2006.
[4] T. P. Sari, "Efektivitas Obat Kumur Tea Tree Oil 0,2% Dalam Menurunkan Jumlah Koloni Bakteri Rongga Mulut Pada Mahasiswa Kepaniteraan Klinik Departemen Bedah Mulut Dan Maksilofasial Fakultas Kedokteran Gigi Usu," Universitas Sumatera Utara, 2018.
[5] N. Jan, K. I. Andrabi, and R. John, "Calendula officinalis - An Important Medicinal Plant with Potential Biological Properties," Proc Indian Natn Sci Acad., vol. 83, no. 4, pp. 769–787, 2017, doi: 10.16943/ptinsa/2017/49126.

This study was designed to assess the general public's perception, knowledge, attitude and behaviour on antibiotic resistance in a Bangalore, a metropolitan city in the south of India. It also tries to decipher whether the level of education and the professional status of an individual has a positive association with the level of knowledge on antibiotic resistance.Of all the participants who participated in the study, around 95.5% of the surveyed population received a university education. About 81.6% of the participants had knowledge about antibiotic resistance and 82.2% of them believed that many...........

Keywords : Antibiotic resistance, Drugs, Internal Medicine

[1]. Alós JI. Resistencia bacteriana a los antibióticos: una crisis global [Antibiotic resistance: A global crisis]. Enferm Infecc Microbiol Clin. 2015 Dec;33(10):692-9. Spanish. doi: 10.1016/j.eimc.2014.10.004. Epub 2014 Dec 1. PMID: 25475657.
[2]. Dever LA, Dermody TS. Mechanisms of bacterial resistance to antibiotics. Arch Intern Med. 1991 May;151(5):886-95. PMID: 2025137.
[3]. Lamberte LE, van Schaik W. Antibiotic resistance in the commensal human gut microbiota. Curr Opin Microbiol. 2022 Aug;68:102150. doi: 10.1016/j.mib.2022.102150. Epub 2022 Apr 28. PMID: 35490629.
[4]. Chinemerem Nwobodo D, Ugwu MC, Oliseloke Anie C, Al-Ouqaili MTS, Chinedu Ikem J, Victor Chigozie U, Saki M. Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace. J Clin Lab Anal. 2022 Sep; 10.10, 36(9):e24655.
[5]. Tarín-Pelló A, Suay-García B, Pérez-Gracia MT. Antibiotic resistant bacteria: current situation and treatment options to accelerate the development of a new antimicrobial arsenal. Expert Rev Anti Infect Ther. 2022 Aug; 10.1080/1478721, 20(8):1095-1108.

Background Corticosteroids are a group of medications that are structurally and pharmacologically similar to the endogenous hormone cortisol. The mechanisms of action for the therapeutic effects and clinical improvement associated with corticosteroids are also responsible for most of the adverse effects associated with its chronic use or its use in high doses. Prescription of corticosteroids is on the increaseamong patients seen in our clinical practice. The increase in steroid prescription is associated with increasing frequency of complications associated with its chronic use. The main objective of this study is to review the prescription pattern of steroids in our practice and to also assess how patients are counselled before they are started on these agents............

Keywords : Corticosteroids, counselling, prescription, adverse effects, Lagos.

[1]. Yasir M, Goyal A, Bansal P, Sonthalia S. Corticosteroid Adverse Effects. (Updated 2021 Mar 3). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK531462/
[2]. Liu, D., Ahmet, A., Ward, L, Krishnamoorthy P, Mandelcorm ED, Leigh R, Brown JP, Cohen A, Kim H. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. All AsthClinImmun 2013; 9: 30. https://doi.org/10.1186/1710-1492-9-30.
[3]. Hengge UR, Ruzicka T, Schwartz RA, Cork MJ. Adverse effects of topical glucocorticosteroids. J Am AcadDermatol. 2006;54(1):1-15; quiz 16-8. DOI: 10.1016/j.jaad.2005.01.010. PMID: 16384751.
[4]. van Staa TP, Leufkens HG, Abenhaim L, Begaud B, Zhang B, Cooper C. Use of oral corticosteroids in the United Kingdom. QJMed. 2000;93(2):105-11. DOI: 10.1093/qjmed/93.2.105. PMID: 10700481.
[5]. Royal College of Physicians Guidelines Writing Group. Glucocorticoid-induced osteoporosis: Guidelines for prevention and treatment. London: Royal College of Physicians, 2002.

Background: ParkiaspeciosaHassk is widely known as stink bean and one of the edible plants that have not been cultivated as medicinal plants yet Materials and Methods:Samples were collected randomly from the local market in Kemaman, Terengganu. The pods were separated from the seed and cleaned thoroughly using tap water. Extraction process by maceration using three solvents, n-hexane, ethyl acetate, and ethanol 95%. Qualitative phytochemical analysis of the extract was determined. Antimicrobial activity using Kirby-Bauer (KB) method. Results: Maceration of ethanol...........

Keywords : Antimicrobial, Parkia speciose Hassk, Kirby-Bauer Disc Susceptibility Test.

[1]. Carvalho, R. S., Carollo, C. A., de Magalhães, J. C., Palumbo, J. M. C., Boaretto, A. G., Nunes e Sá, I. C., Ferreira, J. M. S. (2018). Antibacterial and antifungal activities of phenolic compound-enriched ethyl acetate fraction from Cochlospermumregium (mart. Et. Schr.) Pilger roots: Mechanisms of action and synergism with tannin and gallic acid. South African Journal of Botany, 114, 181–187
[2]. [2] Gan, C., &Latiff, A. A. (2011). Optimisation of the solvent extraction of bioactive compounds from Parkiaspeciosa pod using response surface methodology. Food Chemistry, 124(3), 1277–1283.
[3]. Harborne JB. Phytochemical methods. 2nd Edition,Chapman and Hall, New York, 1987.
[4]. Hasim, Faridah, D. N., &Kurniawati, D. A. (2015). Antibacterial activity of ParkiaspeciosaHassk. peel to Escherichia coli and Staphylococcus aureus bacteria. Journal of Chemical and Pharmaceutical Research, 7(4), 239–243.
[5]. [M Miyazawa; F Osman. Natural Products Letters, 2001, 15(3), 171-176.