Background: Collagen Peptide (CP) specifically that of bovine origin has been studied to have antioxidant properties, promoting synthesis and regeneration of extracellular matrix. Bovine CP (BCP) has been proven effective in improving joint health, overall appearance of hair, owing to the triple helix protein structure that is a vital component of bones, skin, tendons and ligaments.1 Titan Biotech Ltd. has formulated their BCP TitabonTM to be available as a nutraceutical supplement for adults looking to improve general hair health and symptoms associated with osteoarthritis(OA). OA is a leading cause of reduced mobility, increasing pain that interferes with a person's everyday activities and diminishes their quality of life. The current clinical studies conducted on TitabonTM have shown promising results...........

Keywords : Collagen peptide, Bovine Collagen, Collagen for Osteoarthritis, Collagen for Hair.

[1]. Lin, C. R., Tsai, S. H. L., Huang, K. Y., Tsai, P. A., Chou, H., & Chang, S. H. (2023). Analgesic efficacy of collagen peptide in knee osteoarthritis: a meta-analysis of randomized controlled trials. Journal of Orthopaedic Surgery and Research, 18(1), 694.
[2]. Havelin, J., & King, T. (2018). Mechanisms underlying bone and joint pain. Current osteoporosis reports, 16(6), 763-771.
[3]. Silvipriya, K. S., Kumar, K. K., Bhat, A. R., Kumar, B. D., & John, A. (2015). Collagen: Animal sources and biomedical application. Journal of Applied Pharmaceutical Science, 5(3), 123-127.
[4]. Bellamy N, Buchanan WW. A preliminary evaluation of the dimensionality and clinical importance of pain and disability in osteoarthritis of the hip and knee. Clinical Rheumatology. 1986;5:231-241.
[5]. Salaffi F, Stancati A, Silvestri CA, Ciapetti A, Grassi W. Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale. European Journal of Pain. 2004;8:283-291.

Introduction: Ensuring the availability of vaccines determines the expected outcomes of vaccination. This depends on the quality of the logistics cycle put in place. The aim of the study was to take stock of the logistics cycle of vaccines in the Expanded Program on Immunization. Methodology: A mixed-methods study was conducted over a period of 4 months at the Central Coordination of the Expanded Program on Immunization. Document review, complemented by direct observation of storage warehouses, allowed for the evaluation of the quality of the logistics cycle............

Keywords : Vaccines; Supply chain; Expanded Program on Immunization; Cameroon.

[1]. Organisation Mondiale de la Santé (OMS). Global Vaccine Action Plan 2011- 2020. Genève : OMS ; 2011
[2]. OMS, Fonds des Nations Unies pour l'Enfance (UNICEF). Franchir une nouvelle étape dans la gestion des vaccins grâce à l'outil de gestion des stocks en ligne (SMT). Genève : OMS, UNICEF ; 2022
[3]. OMS. Immunization Agenda 2030. Genève : OMS ; 2023
[4]. Organisation des Nations Unies (ONU). Une disparité mondiale existe dans l'accès aux vaccins essentiels [En ligne]. 2022 [Consulté le 29 novembre 2023]. Consultable à l'URL : https://news.un.org/fr/story/2022/11/1129697
[5]. Mkandawire T. Renforcer les chaînes d'approvisionnement de la Santé publique : Un cadre d'intégration. Vill Reach ; 2022

This comprehensive review thoroughly evaluates the state-of-the-art techniques employed in the extraction, fractionation, and analytical profiling of therapeutic bioactives sourced from a diverse array of natural origins. Addressing specialists and researchers in the field, this article offers a systematic examination of advanced methodologies that are integral to the current landscape of bioactive compound research. The review commences by providing an extensive examination of extraction methodologies, highlighting critical parameters such as solvent selection, temperature, and duration to optimize the yield and purity of bioactive compounds. It proceeds to search through advanced fractionation techniques, presenting a detailed comparison of column chromatography, solid-phase extraction, and preparative HPLC, with a focus on their efficacy in the isolation and purification of target compounds............

Keywords : bioactives, plant, phytochemicals, flavonoids, terpenes, extraction, fractionation, purification, modern methods, green techniques, Supercritical, SFE, HPLC

[1] Xiang Q, Li M, Wen J, Ren F, Yang Z, Jiang X and Chen Y 2022 The bioactivity and applications of pomegranate peel extract: A review J Food Biochem 46 e14105
[2] Tedeschi P, Nigro M, Travagli A, Catani M, Cavazzini A, Merighi S and Gessi S 2022 Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease Int J Mol Sci 23
[3] Maayah Z H, Takahara S, Ferdaoussi M and Dyck J R B 2020 The anti-inflammatory and analgesic effects of formulated full- spectrum cannabis extract in the treatment of neuropathic pain associated with multiple sclerosis Inflamm Res 69 549-58
[4] Banerjee S, Anand U, Ghosh S, Ray D, Ray P, Nandy S, Deshmukh G D, Tripathi V and Dey A 2021 Bacosides from Bacopa monnieri extract: An overview of the effects on neurological disorders Phytother Res 35 5668-

Pharmaceutical research has been dedicated to advancing drug delivery methods to enhance therapeutic outcomes and patient adherence. Buccal drug delivery systems, a novel approach, leverage the oral mucosa's unique attributes to provide an alternative to traditional administration routes. This study focuses on the formulation, molecular insights, and therapeutic implications of gabapentin buccal tablets, exploring the potential of this innovative approach. By examining drug formulation, physicochemical attributes, and patient-specific factors, the study reveals the interplay that affects............

Keywords : Mouth dissolving Tablet, Orodispersible Tablets, gabapentin, Buccal drug delivery system.

[1]. Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM. Polymeric systems for controlled drug release. Chemical reviews. 1999 Nov 10;99(11):3181-98.
[2]. Patel A, Cholkar K, Agrahari V, Mitra AK. Ocular drug delivery systems: An overview. World journal of pharmacology. 2013;2(2):47.
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[4]. Govindasamy K. Formulation and In-Vitro Evaluation of Gabapentin Oral Controlled Release Matrix Tablets (Doctoral dissertation, Padmavathi College of Pharmacy and Research Institute, Dharmapuri).
[5]. Akotakar MA, Zanke AA, Ghonge BA. Formulation and Evaluation of Buccal Disintegrating Tablet of Anticonvulsant Drug.

Background: Poison is a substance that causes injury or illness or death, even when taken in a little quantity. Poisoning is a significant global public health problem ranking 45th in total deaths worldwide. Every year half a million people die due to poisoning. The main aim of the study is to assess the incidence and treatment patterns in intentional poisoning patients. Materials and Methods: A prospective observational study for six months duration was conducted at secondary care hospital on 196 cases of Intentional poisoning reported............

Keywords : Intentional poisoning, Antidote, Glasgow coma scale, Drug overdose, secondary care hospital.

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