September - 2021 (Volume-11 ~ Issue-9 ~ Series-1)

Paper Type

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Research Paper

Title

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Comparative study of radiolabeled68Ga DOTANOC acetate, 68Ga PSMA-11 and 68Ga RGD on DEN and Phenobarbitone induced hepatocellualar carcinoma in Sprague dawley rats

Country

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September

Authors

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Malathi Thiyagarajan || Ariharasivakumar. || ArunPandiyan || AjithShinto

Page No.

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01-16

Liver cancer the third most commonly diagnosed cancer and fourth most common cause of mortality. The survival rate can be increased by earlier diagnosis and better treatment regimen. PET/CT has recently become a vital part to achieve this goal by providing the detailed information regarding tumor lesions than other techniques. Combination of FDG PET/CT has been used initially and proven to be of great benefit for the assessment of liver cancer. Due to some limitation of FDG, a new diagnostic tracer has to be introduced. Radiolabelled peptides are widely used now a days for imaging cancer lesions. The present study aimed to compare the three radiolabelled peptides 68Ga DOTA-NOC acetate, 68Ga PSMA-11 and 68Ga RGD efficiency on DEN and Phenobarbitone induced hepatocellular.......

 

 

KEYWORDS: PET/CT, 68Ga DOTA-NOC acetate,68Ga PSMA-11,68Ga RGD, liver cancer

[1]. Anand P, Kunnumakara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, et al. Cancer is a Preventable Disease that Requires Major Lifestyle Changes. Pharmaceutical Research. 2008;25(9):2097–116.
[2]. http://cancer.emedtv.com/liver-cancer/liver-cancer.html [3]. Okarvi SM. Peptide‐based radiopharmaceuticals: Future tools for diagnostic imaging of cancers and other diseases. Medicinal research reviews. 2004 May;24(3):357-97.[4]. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA: a cancer journal for clinicians. 2019 Jan;69(1):7-34. [5]. PRESS RELEASE N° 263 12 September 2018 - who.int [Internet]. [cited 2019May7]. Available from: https://www.who.int/cancer/PRGlobocanFinal.pdf


Paper Type

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Research Paper

Title

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Evaluation of Knowledge And Attitude Of non-Narcotic Analgesic Self-Medication Among Grade 12 Pharmacy Students Of Citra Medika Magelang Vocational High School

Country

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Authors

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Zulkarnia Sofa || Riyan Setiyanto || Makmun Syaifudin

Page No.

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17-22

The increase in the number of Indonesian people's self-medication in both chemical and traditional medicine has been described by the Central Statistics Agency in 2019, namely an increase of 0.72% from 2018 to 71.46% in 2019. The high number of self-medication requires a capable pharmaceutical worker. understand how self-medication. The purpose of this research is to evaluate the knowledge and behavior of non-narcotic analgesic drugs among 12th-grade pharmacy students of Citra Medika Vocational High School, Magelang City as prospective pharmaceutical technical personnel...........

 

Keywords: Self-medication, analgesic, evaluation

[1] World Health Organization, Guidelines For The Regulatory Assessment of Medicinal Products For Use In Self-Medication. Geneva: World Health Organization, 2000.
[2] A. Mansjoer, Capita Selecta Medicine Volume 1, 3rd ed. Jakarta: Media Aesculapius, 2000.
[3] Sylvie Fainzang, Self-Medication and Society Mirages of Autonomy, 1st ed. Routllege Falmer, 2020.
[4] Minister of Health of the Republic of Indonesia, "Regulation of the Minister of Health of the Republic of Indonesia Number 919/MenKes/PER/X/1993 concerning Criteria for Drugs that Can be Dispensed Without a Prescription," Regul. Minist. Heal. Repub. Indones., vol. 16, no. 1, pp. 1988–1989, 1993.
[5] Central Bureau of Statistics, "Percentage of Population Self-medicating During the Last Month, 2017-2019." National Socio-Economic Survey, Jakarta, 2019, [Online]. Available: https://www.bps.go.id/indicator/30/224/1/persentase-penduduk-yang-mengobati-sendiri-selama-sebulan-terakhir.html.


Paper Type

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Research Paper

Title

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Synthesis of some novel Pyrimidine derivatives and compared to available antimicrobial (MTCC inhibitors) drugs

Country

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India

Authors

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B.P. Yadav || Ajit Joshi || Meenakshi Thakur

Page No.

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23-28

A new series of pyrimidine derivatives have been synthesized by reacting substituted pyrimidine carboxylic acid with substituted aniline to get substituted pyrimidine amide (3), which was de-methylated using BBr3 to form hydroxy derivative of substituted pyrimidine amide (4). This was further alkylated with respective alkyl halide to synthesize substituted pyrimidine derivatives (5)...

 

Keywords:Multi-component reactions, Pyrimidine derivative, antimicrobial activity, minimum inhibitory concentration (MIC).

[1]. Giller, S. A., Zhuk, R. A., Lidak, M.I. U., Dokl. Akad. Nauk.SSR. 1967, 176, 332-335.
[2]. Curreri, A. R., Ansfield, R. J., McIver, F. H., Waisman, H. A., Hedelberger., C. Cancer Res., 1958, 18, 478-484.
[3]. Chaudhary, N. K., Montag, B. J., Heidelberger., C. Cancer Res. 1958, 18, 318-328.
[4]. Malik,V., Singh, P., Kumar, S., Tetrahedron. 2006, 62, 5944-5951.
[5]. AntonínHolý, Ivan Votruba and Milena Masojídková,J. Med. Chem. 2002, 45, 1918–1929.


Paper Type

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Research Paper

Title

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Formulation and Physical Evaluation of Toothpaste from the Combination of Breadfruit Leaves Extract (Artocarpus altilis) and Lime (Citrus aurantifolia)

Country

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Indonesia

Authors

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Iin Suhesti || Imelda Stevani Adilia || Makmun Syaifudin

Page No.

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29-35

Breadfruit leaves (Artocarpus altilis) contain of antibacterial substances toward Streptococcus mutans causing dental caries, with the inhibition in amount of 21,37 mm in the concentration of 20% (very strong). Besides caries, the teeth color is also known as a dental problem that has a relation with someone's aesthetic. Lime (Citrus aurantifolia) is one of the natural ingredientsthat contain of citric acid that can be used as the teeth whitener. This observation was intended to know about the formula and physical evaluation of toothpaste also to find out theeffect of variation of breadfruit leaves extract concentration to the physical evaluation of toothpaste. This observation used experimental method with 3 variation of breadfruit leaves extract concentration in amount of 20%, 15%, 10%. The result that obtained (numeric data) was analyzed by SPSS with Kruskall-Wallis test for the.........

 

KEYWORDS: PCOS, Toothpaste, breadfruit leaves extract, lime, physical evaluation

[1]. Depkes RI. (1995). Indonesian Pharmacope 4th edition. Jakarta: Departemen Kesehatan Republik Indonesia.
[2]. Yuliastri, Wa Ode, dkk. (2019). Breadfruit Leaves (Artocarpus altilis) Herbal Toothpaste Formulation and Its Antibacterial Activity Test Towards Streptococcus mutans. Indonesia Mandala Pharmacon Journal, Vol. 05, No. 01. https://doi.org/10.35311/jmpi.v5i01.35.
[3]. Bempa, S. L. P., Fatimawali., & Perengkuan, W. G. (2016). Breadfruit Leaves Extract (Artocarpus altilis) Inhibition Test On Bacteria Streptococcus mutansGrowth. Pharmacon, Vol.5, No. 4. 2302-2493. https://doi.org/10.35799/pha.5.2016.13967.
[4]. Makasenda, E. F. ., Wicaksono, D. A., & Khoman, J. A. (2018). The Discoloration of Composite Resin On Immersion In Vinegar (Asetic acid ) and Lime (Citrus aurantifolia). E-GIGI. https://doi.org/10.35790/eg.6.2.2018. 20149
[5]. Prastiwi, S. S., & Ferdiansyah, F. (2017). Article Review: The Subtances and Pharmacological Activity of (Citrus aurantifolia s.). Farmaka.