October - 2020 (Volume-10 ~ Issue-10 ~ Series-1)

Paper Type

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Research Paper

Title

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Recent Updateson Cocrystals Technologieson Enhancement of Solubilityofthe Drugs

Country

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India

Authors

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Boopathy Raja || Udhumansha Ubaidulla || Grace Rathnam

Page No.

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01-12

Pharmaceutical co-crystals have acquired vast improvement in recent years due to its ability to change physicochemical properties of drugs. Pharmaceutical co-crystal consists of active pharmaceutical ingredient (API) and coformers. Co-crystals can be utilized to improve imperative physicochemical attributes of a medication, including solvency, disintegration, bioavailability and solidness of API while keeping up its therapeutic activity. Expanded commercialization of cocrystals has thus required extra research on techniques to make cocrystals, with specific highlight put on rising innovations that can be produced naturally attractive and efficient choices. In this review, well-organized and ordered overview of pharmaceutical cocrystal is provided, focusing on the solids forms of API, design strategy, its method of preparation, physicochemical properties, mechanism of enhancing solubility and its characterization technique. An overview of applications and marketed drug products of cocrystals is also described.

 

Keywords: Pharmaceutical co-crystals, physicochemical properties, cocrystallization, solubility, stability.

[1]. Sohrab M , Mahapatra S.P: Pharmaceutical Co-crystal. A New Paradigm for Enhancing the Physicochemical Properties of Active Pharmaceutical Ingredient. International journal of pharmacy and life sciences. 2015;6(3):4324-33.
[2]. Aakeröy CB, Salmon DJ.Building co-crystals with molecular sense and supramolecular sensibility. CrystEngComm. 2005;7:439-448.
[3]. Shan N, Zaworotko MJ. The role of cocrystals in pharmaceutical science. Drug discovery today. 2008;13(9-10):440-6.
[4]. Ter Horst JH, Deij MA, Cains PW. Discovering new co-crystals. Crystal Growth and Design. 2009;9(3):1531-7.
[5]. Schultheiss N, Newman A. Pharmaceutical cocrystals and their physicochemical properties. Crystal growth and design. 2009;9(6):2950-67.

 

Paper Type

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Research Paper

Title

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Reactions of Renal Calculi with Natural Product (Phyllanthus Niruri Leaves Extract) and Heterocyclic Acid (Nicotinic Acid)

Country

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Sri Lanka

Authors

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Dr. Alokita Kashyap || Dr. Madhu Kumari Gupta

Page No.

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13-18

Urolithiasis is a complex process results from a succession of several physiochemical events including super saturation, nucleation, growth, aggregation and retention, within the kidneys. Traces of impurities cause marked modification in the growth and habit of both soluble and insoluble metal salts. It has been reported that strong absorption occurs on certain crystal faces only, and their rate of growth is markedly reduced, this may be due to formation of complexes with the additives. These complexing agents when complexed through polar groups are especially effective. This has further demonstrated that such absorption is much more active in solutions of the highly soluble metal salts than on the sols of less soluble metal salts of complexing cation...........

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Paper Type

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Research Paper

Title

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Nanostructured Lipid Carriers: An Excellent Tool for Drug Delivery

Country

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India

Authors

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Dr. S.C. Arora || Chahat || Anuradha Kush

Page No.

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19-27

Nanocarriers present a great approach in drug delivery. Nanostructured lipid carriers (NLCs) are a recent approach for the delivery of poorly soluble drugs with low oral bioavailability. Nanostructured Lipid Carriers (NLCs) are mixture of solid lipids along with spatially incompatible liquid lipids. It remains solid at room temperature. It also overcomes the disadvantages of various lipid particulate carriers. The present review gives insights on the definitions and characterization of NLC as colloidal carriers including the production techniques.

 

Keywords: Nanotechnology, targeted drug delivery, nanocarrier, NLCs.

[1]. Mehnert W, Mader K. Solid lipid nanoparticles: Production, characterization and applications. Adv Drug Deliv Rev., 2001, 47; 165-196.
[2]. Carmona-Ribeiro AM. Biomimetic nanoparticles: Preparation, characterization and biomedical applications. Int J Nanomed., 2010, 5; 249-259.
[3]. Mishra B, Patel BB, Tiwari S. Colloidal nanocarriers: A review on formulation technology, types and applications toward targeted drug delivery. Nanomedic., 2010, 6; 9-24.
[4]. Mujoriya R, Bodla RB, Dhamande K, Singh D, Patle L. Niosomal drug delivery system: The magic bullet. J Appl Pharm Sci., 2011, 01(09); 20-23.
[5]. Mehnert W, Mader K, Solid lipid nanoparticles: Production, characterization and applications. Adv Drug Deliv Rev., 2001, 47(2-3); 96-165.

 

Paper Type

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Research Paper

Title

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xxxxxxx

Country

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xxx

Authors

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xxx

Page No.

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28-40

Cancer is major health problem in both developed and developing countries. Cancer after cardiovascular disease is the second leading cause of death. Cancer is the abnormal growth of cells in our bodies that can lead to death. Because of high death rate associated with cancer and because of serious side effects of chemotherapy and radiation therapy, many cancer patients seek alternative complementary methods of treatment. Plants have been used for treating diseases since time immemorial. More than 50% of modern drugs in clinical use are of natural products. In the present review, an attempt has been made to study the plants that have been used in the treatment of cancer.

 

Keywords: Cancer, Herbal, Leukemias

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